验证数据展示
经过测试的应用
| Positive WB detected in | BxPC-3 cells, PC-3 cells, U-251 cells, SK-BR-3 cells, MDA-MB-231 cells, LN-229 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:5000-1:50000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
86962-12-RR targets KAT6B/MORF in WB, ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | MYST histone acetyltransferase (monocytic leukemia) 4 |
| 别名 | MYST4, Histone acetyltransferase MORF, Histone acetyltransferase MOZ2, KAT6B, KIAA0383 |
| 计算分子量 | 2073 aa, 231 kDa |
| 观测分子量 | 231-250 kDa |
| GenBank蛋白编号 | BC150618 |
| 基因名称 | MYST4 |
| Gene ID (NCBI) | 23522 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q8WYB5 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
KAT6B (also known as MORF or MYST4) is a member of the MYST family of histone acetyltransferases that catalyzes acetylation of histones H3 and H4, thereby regulating chromatin structure and gene transcription. It plays essential roles in brain development, hematopoiesis, and skeletal morphogenesis. Mutations in the KAT6B gene cause developmental disorders such as Genitopatellar syndrome and Ohdo syndrome, while chromosomal translocations generating KAT6B-CREBBP fusion proteins drive a subset of acute myeloid leukemia.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for KAT6B/MORF antibody 86962-12-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
