验证数据展示
产品信息
86962-12-PBS targets KAT6B/MORF in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | MYST histone acetyltransferase (monocytic leukemia) 4 |
| 别名 | MYST4, Histone acetyltransferase MORF, Histone acetyltransferase MOZ2, KAT6B, KIAA0383 |
| 计算分子量 | 2073 aa, 231 kDa |
| 观测分子量 | 231-250 kDa |
| GenBank蛋白编号 | BC150618 |
| 基因名称 | MYST4 |
| Gene ID (NCBI) | 23522 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q8WYB5 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
KAT6B (also known as MORF or MYST4) is a member of the MYST family of histone acetyltransferases that catalyzes acetylation of histones H3 and H4, thereby regulating chromatin structure and gene transcription. It plays essential roles in brain development, hematopoiesis, and skeletal morphogenesis. Mutations in the KAT6B gene cause developmental disorders such as Genitopatellar syndrome and Ohdo syndrome, while chromosomal translocations generating KAT6B-CREBBP fusion proteins drive a subset of acute myeloid leukemia.
