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JNJ-61432059

CAS号

2035814-50-5

分子式

C25H22FN5O2

主要靶点

iGluR

仅限科研使用

Cat No : CM02671

Print datasheet

Synonyms

AMPAR|iGluR|Ionotropic glutamate receptors|JNJ 61432059|JNJ61432059|JNJ-61432059|Inhibitor|inhibit

验证数据展示

  • CAS No.: 2035814-50-5

    JNJ-61432059
    CAS#: 2035814-50-5

产品信息

CAS号 2035814-50-5
分子式 C25H22FN5O2
主要靶点 iGluR
主要通路 离子通道|神经科学
分子量 443.47
纯度 98.13%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 AMPAR|iGluR|Ionotropic glutamate receptors|JNJ 61432059|JNJ61432059|JNJ-61432059|Inhibitor|inhibit

靶点活性

AMPAR:(pic50)9.7

体内活性

在小鼠海马体中，展现出时间和剂量依赖性的AMPAR/γ-8受体占有率，从而在角膜电击和戊四氮（PTZ）抗惊厥模型中提供了强有力的癫痫保护作用。

溶解度

DMSO:65 mg/mL (146.57 mM)

参考文献

1.Savall BM, et al. Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators. ACS Med Chem Lett. 2018 Dec 26;10(3):267-272.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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