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验证数据展示

  • WB analysis using 34193-1-AP (same clone as 34193-1-PBS)

    WB analysis using 34193-1-AP (same clone as 34193-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 34193-1-AP (JAGN1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 34193-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 34193-1-AP (same clone as 34193-1-PBS)

    IHC staining of human colon cancer using 34193-1-AP (same clone as 34193-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 34193-1-AP (JAGN1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 34193-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 34193-1-AP (same clone as 34193-1-PBS)

    IHC staining of human colon cancer using 34193-1-AP (same clone as 34193-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 34193-1-AP (JAGN1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 34193-1-PBS in a different storage buffer formulation.

JAGN1 Polyclonal antibody, PBS Only

JAGN1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 34193-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

Protein jagunal homolog 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

34193-1-PBS targets JAGN1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag40789

Product name: Recombinant human JAGN1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-39 aa of BC032101

Sequence: MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 jagunal homolog 1 (Drosophila)
别名 Protein jagunal homolog 1
计算分子量 183 aa, 21 kDa
观测分子量 21 kDa
GenBank蛋白编号BC032101
基因名称 JAGN1
Gene ID (NCBI) 84522
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ8N5M9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Jagunal homolog 1 (JAGN1) is an evolutionarily conserved endoplasmic reticulum (ER) membrane protein essential for neutrophil differentiation and function. First identified in Drosophila for its role in ER organization, human JAGN1 mutations cause severe congenital neutropenia type 5, characterized by recurrent infections due to impaired granulocyte development. JAGN1 regulates glycoprotein folding, ER-Golgi trafficking, and N-glycosylation of proteins critical for neutrophil viability. Loss of JAGN1 leads to ER stress, apoptosis of myeloid progenitors, and defective neutrophil migration. Its indispensable role in innate immunity highlights JAGN1 as a potential therapeutic target for neutropenia and immunodeficiency disorders (PMID: 25129144; 37120535; 33207009; 38739706).

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