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Ionomycin

CAS号

56092-81-0

分子式

C41H72O9

主要靶点

Others

仅限科研使用

Cat No : CM06928

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Synonyms

Ionomycin

验证数据展示

  • CAS No.: 56092-81-0

    Ionomycin
    CAS#: 56092-81-0

产品信息

Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+). It is produced by the bacterium Streptomyces conglobatus.It is used in research to raise the intracellular calcium level (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. Ionomycin promotes apoptosis and induces the activation of protein kinase C (PKC).

CAS号 56092-81-0
分子式 C41H72O9
主要靶点 Others
主要通路 其他
分子量 709.01
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 2 years
别名 Ionomycin

体外活性

Ionomycin (2 μM) induced cell death in LCLC 103H cells, derived from a human large cell lung carcinoma, by inducing calpain activation promotes decrease of Bcl-2 proteins thereby triggering the intrinsic apoptotic pathway [2].Ionomycin also phosphorylate p38 MAPK by Ca2+ influx through SOCE, leading to suppression of TNF-α-induced NF-κB phosphorylation[3].

溶解度

Ethanol: 90.0 mg/mL (126.9 mM), sonification is recommended. DMSO: 90.0 mg/mL (126.9 mM), sonification is recommended.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2