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验证数据展示

  • WB analysis of fetal human brain using 21862-1-AP (same clone as 21862-1-PBS)

    WB analysis of fetal human brain using 21862-1-AP (same clone as 21862-1-PBS)

    fetal human brain tissue were subjected to SDS PAGE followed by western blot with 21862-1-AP (Intersectin 1 antibody at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21862-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach using 21862-1-AP (same clone as 21862-1-PBS)

    IHC staining of human stomach using 21862-1-AP (same clone as 21862-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human normal stomach slide using 21862-1-AP (Intersectin 1 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21862-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Intersectin 1/ITSN1 antibody included
  • IHC staining of human stomach using 21862-1-AP (same clone as 21862-1-PBS)

    IHC staining of human stomach using 21862-1-AP (same clone as 21862-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human normal stomach slide using 21862-1-AP (Intersectin 1 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21862-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Intersectin 1/ITSN1 antibody included

Intersectin 1 Polyclonal antibody, PBS Only

Intersectin 1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 21862-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

ITSN1, SH3 domain-containing protein 1A, ITSN 1, ITSN, Intersectin-1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy Intersectin 1/ITSN1 Ready-To-Use IHC Kit. Intersectin 1/ITSN1 primary antibody included.

产品信息

21862-1-PBS targets Intersectin 1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag16517

Product name: Recombinant human ITSN1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 610-926 aa of BC116186

Sequence: LREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 intersectin 1 (SH3 domain protein)
别名 ITSN1, SH3 domain-containing protein 1A, ITSN 1, ITSN, Intersectin-1
计算分子量 1721 aa, 195 kDa
观测分子量 150 kDa
GenBank蛋白编号BC116186
基因名称 Intersectin 1
Gene ID (NCBI) 6453
RRIDAB_2878931
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ15811
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Intersectin 1 (ITSN1) is a multidomain adaptor protein that plays a crucial role in various cellular processes, particularly in the nervous system. It is involved in clathrin-mediated endocytosis, signal transduction, and the regulation of the actin cytoskeleton. The protein is highly abundant in neurons and has been implicated in neurodevelopmental disorders, such as autism spectrum disorders, intellectual disability, and epilepsy. Recent studies have identified de novo variants in the ITSN1 gene in patients with these disorders, suggesting a link between ITSN1 and brain development.

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