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验证数据展示

  • WB analysis using 66922-2-Ig (same clone as 66922-2-PBS)

    WB analysis using 66922-2-Ig (same clone as 66922-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66922-2-Ig (Integrin Beta 4 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66922-2-PBS in a different storage buffer formulation.

  • IHC staining of human skin cancer using 66922-2-Ig (same clone as 66922-2-PBS)

    IHC staining of human skin cancer using 66922-2-Ig (same clone as 66922-2-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 66922-2-Ig (Integrin Beta 4 antibody) at dilution of 1:2000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66922-2-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ITGB4 antibody included
  • IHC staining of human skin cancer using 66922-2-Ig (same clone as 66922-2-PBS)

    IHC staining of human skin cancer using 66922-2-Ig (same clone as 66922-2-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 66922-2-Ig (Integrin Beta 4 antibody) at dilution of 1:2000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66922-2-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ITGB4 antibody included
  • IF Staining of A431 using 66922-2-Ig (same clone as 66922-2-PBS)

    IF Staining of A431 using 66922-2-Ig (same clone as 66922-2-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed A431 cells using Integrin Beta 4 antibody (66922-2-Ig, Clone: 1C2A11 ) at dilution of 1:2000 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66922-2-PBS in a different storage buffer formulation.

Integrin Beta 4 Monoclonal antibody, PBS Only

Integrin Beta 4 Monoclonal Antibody for WB, IHC, IF/ICC, ELISA
Cat No. 66922-2-PBS

产品说明书

CloneNo. 1C2A11

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, IHC, IF/ICC, ELISA

别名

ITGB4, 1C2A11, CD104, GP150, Integrin beta-4

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy ITGB4 Ready-To-Use IHC Kit. ITGB4 primary antibody included.

产品信息

66922-2-PBS targets Integrin Beta 4 in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag17395

Product name: Recombinant human Integrin beta-4 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 27-354 aa of BC126411

Sequence: ANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSN

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 integrin, beta 4
别名 ITGB4, 1C2A11, CD104, GP150, Integrin beta-4
计算分子量 1752 aa, 195 kDa
观测分子量 200-210 kDa
GenBank蛋白编号BC126411
基因名称 Integrin beta 4
Gene ID (NCBI) 3691
RRIDAB_2882249
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDP16144
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin beta-4 is predominantly expressed in squamous epithelial cells, endothelial cells, immature thymocytes, Schwann cells, and fibroblasts of the peripheral nervous system (PMID: 28084395). Integrin beta-4 pairs with alpha-6, and the heterodimeric integrin alpha-6/beta-4 is a receptor for laminin. Integrin alpha-6/beta-4 plays a critical structural role in the hemidesmosome of epithelial cells, and also plays a role in the invasive and metastatic phenotype of various cancers.

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