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验证数据展示

  • FC experiment of mouse splenocytes using 98024-1-RR (same clone as 98024-1-PBS)

    FC experiment of mouse splenocytes using 98024-1-RR (same clone as 98024-1-PBS)

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD126/IL-6R alpha Rabbit Recombinant Antibody (98024-1-RR, Clone: 230371A7) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Mouse CD4 (GK1.5) (CL647-65104, Clone: GK1.5). Cells were not fixed. This data was developed using the same antibody clone with 98024-1-PBS in a different storage buffer formulation.

  • FC experiment of mouse splenocytes using 98024-1-RR (same clone as 98024-1-PBS)

    FC experiment of mouse splenocytes using 98024-1-RR (same clone as 98024-1-PBS)

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD126/IL-6R alpha Rabbit Recombinant Antibody (98024-1-RR, Clone:230371A7) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98024-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98024-1-RR

    Affinity and Kinetic Characterization of 98024-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98024-1 -RR against Mouse IL-6R alpha were performed. The affinity constant is 0.629 nM.

Anti-Mouse CD126/IL-6R alpha Rabbit Recombinant Antibody, PBS Only

CD126/IL-6R alpha Uni-rAb® Recombinant Antibody for FC
Cat No. 98024-1-PBS

产品说明书

CloneNo. 230371A7

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

CD126, Il6ra, 230371A7, IL 6R, Il6r

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98024-1-PBS targets CD126/IL-6R alpha in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原

CatNo: Eg0664

Product name: Recombinant Mouse CD126/IL-6R alpha protein (His Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS

Tag: C-10*His

Domain: 20-357 aa of NM_010559.3

Sequence: LVLGSCRALEVANGTVTSLPGATVTLICPGKEAAGNVTIHWVYSGSQNREWTTTGNTLVLRDVQLSDTGDYLCSLNDHLVGTVPLLVDVPPEEPKLSCFRKNPLVNAICEWRPSSTPSPTTKAVLFAKKINTTNGKSDFQVPCQYSQQLKSFSCQVEILEGDKVYHIVSLCVANSVGSKSSHNEAFHSLKMVQPDPPANLVVSAIPGRPRWLKVSWQHPETWDPSYYLLQFQLRYRPVWSKEFTVLLLPVAQYQCVIHDALRGVKHVVQVRGKEELDLGQWSEWSPEVTGTPWIAEPRTTPAGILWNPTQVSVEDSANHEDQYESSTEATSVLAPVQE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 6 receptor, alpha
别名 CD126, Il6ra, 230371A7, IL 6R, Il6r
计算分子量50KD
GenBank蛋白编号NM_010559.3
基因名称 Il6ra
Gene ID (NCBI) 16194
RRIDAB_3672168
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP22272
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL-6R alpha, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL-6R alpha, the complex of IL-6 and IL-6R alpha associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL-6R alpha is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892).

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