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验证数据展示

  • WB analysis using 12193-1-AP (same clone as 12193-1-PBS)

    WB analysis using 12193-1-AP (same clone as 12193-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12193-1-AP (ITM2B antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12193-1-PBS in a different storage buffer formulation.

  • WB analysis using 12193-1-AP (same clone as 12193-1-PBS)

    WB analysis using 12193-1-AP (same clone as 12193-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12193-1-AP (ITM2B antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12193-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 12193-1-AP (same clone as 12193-1-PBS)

    IHC staining of mouse kidney using 12193-1-AP (same clone as 12193-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 12193-1-AP (ITM2B antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12193-1-PBS in a different storage buffer formulation.

ITM2B Polyclonal antibody, PBS Only

ITM2B Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 12193-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

ABRI, Bri, BRI2, BRI2 intracellular domain, BRI2, membrane form

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

12193-1-PBS targets ITM2B in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag2831

Product name: Recombinant human ITM2B protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-266 aa of BC016148

Sequence: MVKVTFNSALAQKETKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKFAVETLICS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 integral membrane protein 2B
别名 ABRI, Bri, BRI2, BRI2 intracellular domain, BRI2, membrane form
计算分子量 266 aa, 30 kDa
观测分子量 40 kDa
GenBank蛋白编号BC016148
基因名称 ITM2B
Gene ID (NCBI) 9445
RRIDAB_3669134
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9Y287
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ITM2B plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. It plays a role in the induction of neurite outgrowth and functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.

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