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验证数据展示

  • FC experiment of human peripheral blood leukocytes using 98150-2-RR (same clone as 98150-2-PBS)

    FC experiment of human peripheral blood leukocytes using 98150-2-RR (same clone as 98150-2-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone:241673D3) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98150-2-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocytes using 98150-2-RR (same clone as 98150-2-PBS)

    FC experiment of human peripheral blood leukocytes using 98150-2-RR (same clone as 98150-2-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody (98150-2-RR, Clone: 241673D3) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9)(blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98150-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98150-2-RR

    Affinity and Kinetic Characterization of 98150-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98150-2-RR against Human IL-18R1/CD218a were performed. The affinity constant is 0.915 nM.

Anti-Human IL-18R1/CD218a Rabbit Recombinant Antibody, PBS Only

IL-18R1/CD218a Uni-rAbTM Recombinant Antibody for FC
Cat No. 98150-2-PBS

产品说明书

CloneNo. 241673D3

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

IL18R1, 241673D3, CD218 antigen-like family member A, CD218a, EC:3.2.2.6

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98150-2-PBS targets IL-18R1/CD218a in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 18 receptor 1
别名 IL18R1, 241673D3, CD218 antigen-like family member A, CD218a, EC:3.2.2.6
计算分子量 541 aa, 62 kDa
GenBank蛋白编号BC093975
基因名称 IL18R1
Gene ID (NCBI) 8809
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ13478
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IL-18R1 (CD218a) is a component of the interleukin-18 receptor (IL-18R) complex, which is critical for the signaling of IL-18, a pro-inflammatory cytokine. This receptor complex, consisting of IL-18R1 and the IL-18 receptor accessory protein (IL-18RAP), belongs to the immunoglobulin-like family of interleukin-1 receptors (PMID: 35461924). IL-18R1 plays a significant role in inducing the production of interferon-gamma (IFN-γ) and other inflammatory cytokines, contributing to innate and adaptive immune responses (PMID: 2550053). It is also suggested to play a role in hypertension and chronic kidney disease, where the IL-18/IL-18R1 signaling axis may have diagnostic and therapeutic potential (PMID: 35461924).