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验证数据展示

  • FC experiment of Transfected HEK-293T using 98556-1-RR (same clone as 98556-1-PBS)

    FC experiment of Transfected HEK-293T using 98556-1-RR (same clone as 98556-1-PBS)

    1x10^6 HEK-293T cells or IL-17C transfected HEK-293T cells were intracellularly stained with 0.25 ug Anti-Mouse IL-17C Rabbit RecAb (98556-1-RR, Clone: 250601C2) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98556-1-PBS in a different storage buffer formulation.

  • FC experiment of Transfected HEK-293T using 98556-1-RR (same clone as 98556-1-PBS)

    FC experiment of Transfected HEK-293T using 98556-1-RR (same clone as 98556-1-PBS)

    1x10^6 HEK-293T cells or IL-17C transfected HEK-293T cells were intracellularly stained with 0.25 ug Anti-Mouse IL-17C Rabbit RecAb (98556-1-RR, Clone: 250601C2) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98556-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98556-1-RR

    Affinity and Kinetic Characterization of 98556-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98556-1-RR against Mouse IL-17C were performed. The affinity constant is 1.83 nM.

Anti-Mouse IL-17C Rabbit Recombinant Antibody, PBS Only

IL-17C Uni-rAb® Recombinant Antibody for FC (Intra)
Cat No. 98556-1-PBS

产品说明书

CloneNo. 250601C2

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC (Intra)

别名

Cytokine CX2, Il 17c, Il17c, Interleukin-17C

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98556-1-PBS targets IL-17C in FC (Intra) applications and shows reactivity with mouse samples.

经测试应用 FC (Intra) Application Description
经测试反应性 mouse
免疫原

CatNo: Eg2840

Product name: Recombinant Mouse IL-17C protein (rFc Tag)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 15-194 aa of NM_145834.3

Sequence: HQDPPSWGKPRSHRTLRCYSAEELSHGQAPPHLLTRSARWEQALPVALVASLEATGHRRQHEGPLAGTQCPVLRPEEVLEADTHERSISPWRYRIDTDENRYPQKLAVAECLCRGCINAKTGRETAALNSVQLLQSLLVLRRQPCSRDGTADPTPGSFAFHTEFIRVPVGCTCVLPRSTQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 17C
别名 Cytokine CX2, Il 17c, Il17c, Interleukin-17C
计算分子量22 kDa
GenBank蛋白编号NM_145834.3
基因名称 Il17c
Gene ID (NCBI) 234836
RRIDAB_3746176
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ8K4C5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IL-17C is a member of the IL-17 cytokine family, was cloned from a human fetal kidney library in 2000 (PMID: 10639155). The IL-17 family comprises at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins that induce local cytokine production and recruit granulocytes to sites of inflammation (PMID: 15485625; 11574464). IL-17C is selectively induced in epithelia by bacterial challenge and inflammatory stimuli (PMID: 21993848). IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection (PMID: 21993849).

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