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验证数据展示

  • FC experiment of BALB/c spleen cells using 98341-1-RR (same clone as 98341-1-PBS)

    FC experiment of BALB/c spleen cells using 98341-1-RR (same clone as 98341-1-PBS)

    1x10^6 untreated or anti-CD3/CD28 treated BALB/c spleen cells were surface stained with 0.25 ug Anti-Mouse ICOS/CD278 Rabbit RecAb (98341-1-RR, Clone: 242639C3) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 488 Anti-Mouse CD3. Cells were not fixed. This data was developed using the same antibody clone with 98341-1-PBS in a different storage buffer formulation.

  • FC experiment of BALB/c spleen cells using 98341-1-RR (same clone as 98341-1-PBS)

    FC experiment of BALB/c spleen cells using 98341-1-RR (same clone as 98341-1-PBS)

    1x10^6 anti-CD3/CD28 treated BALB/c spleen cells were surface stained with 0.25 ug Anti-Mouse ICOS/CD278 Rabbit RecAb (98341-1-RR, Clone: 242639C3) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated BALB/c spleen cells were surface stained with 0.25 ug Anti-Mouse ICOS/CD278 Rabbit RecAb (98341-1-RR, Clone: 242639C3) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98341-1-PBS in a different storage buffer formulation.

Anti-Mouse ICOS/CD278 Rabbit Recombinant Antibody, PBS Only

ICOS/CD278 Uni-rAb® Recombinant Antibody for FC
Cat No. 98341-1-PBS

产品说明书

CloneNo. 242639C3

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

242639C3, Activation-inducible lymphocyte immunomediatory molecule, Ailim, CCLP, CD278

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98341-1-PBS targets ICOS/CD278 in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原

CatNo: Eg3198

Product name: Recombinant Mouse ICOS/CD278 protein (rFc Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-rFc

Tag: C-rFc

Domain: 21-144 aa of NM_017480.2

Sequence: EINGSADHRMFSFHNGGVQISCKYPETVQQLKMRLFREREVLCELTKTKGSGNAVSIKNPMLCLYHLSNNSVSFFLNNPDSSQGSYYFCSLSIFDPPPFQERNLSGGYLHIYESQLCCQLKLWL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 inducible T-cell co-stimulator
别名 242639C3, Activation-inducible lymphocyte immunomediatory molecule, Ailim, CCLP, CD278
计算分子量23kDa
GenBank蛋白编号NM_017480.2
基因名称 Icos
Gene ID (NCBI) 54167
RRIDAB_3745991
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9WVS0
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Inducible T cell co-stimulator (ICOS) is related to the CD28 superfamily and is highly expressed on activated T cells as well as regulatory T cells and is crucial for the survival and function of T cells, Th2 cell differentiation, and lung inflammatory responses. Binding ICOS to ICOS-ligand (ICOS-L) activates a cascade of intracellular signaling molecules that prevent apoptosis and lead to the production of cytokines such as IL-4 and IL-13.

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