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Recombinant Human Complement C6 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg4529

Print datasheet

Synonyms

C6, complement component 6, Complement component C6

验证数据展示

  • Purity of Recombinant Human Complement C6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Complement C6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human Complement C6 protein Cys22-Ala934 (Accession# P13671) with a rabbit IgG Fc tag at the C-terminus.
基因ID 729
蛋白编号 P13671
预测分子量 128.7 kDa
SDS-PAGE 120-130 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Complement C6 protein is part of the complement system and is a key component of the Membrane Attack Complex (MAC), which acts by forming pores in the plasma membrane of target cells in both natural and adaptive immune responses. The C6 protein plays a cytolytic role in the complement pathway and is involved in the immune response and cytolysis process. Together with other components of the complement cascade, it labels and removes pathogens and damaged cells. C6 proteins have been implicated in a variety of diseases, including meningitis and brucellosis. C6 complement deficiency prevents the development of diet-induced atherosclerosis. Drug development for C6 is currently underway.

参考文献:

1. Karadadas E, et al. Clin Biochem. 2020;81:15-19.                                                      
2. Lin K, et al. Blood Adv. 2020;4(9):2049-2057.