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验证数据展示

  • WB analysis using 11419-1-AP (same clone as 11419-1-PBS)

    WB analysis using 11419-1-AP (same clone as 11419-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11419-1-AP (HOPX antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11419-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 11419-1-AP (same clone as 11419-1-PBS)

    IHC staining of human placenta using 11419-1-AP (same clone as 11419-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 11419-1-AP (HOPX antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11419-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 11419-1-AP (same clone as 11419-1-PBS)

    IHC staining of human placenta using 11419-1-AP (same clone as 11419-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 11419-1-AP (HOPX antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11419-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

HOPX Polyclonal antibody, PBS Only

HOPX Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 11419-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

11419-1-PBS targets HOPX in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag1979

Product name: Recombinant human HOPX protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-73 aa of BC014225

Sequence: MSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSEGLPSECRSVID

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 HOP homeobox
别名
计算分子量 73 aa, 8 kDa
观测分子量 8-12 kDa
GenBank蛋白编号BC014225
基因名称 HOPX
Gene ID (NCBI) 84525
RRIDAB_10693525
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BPY8
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

HOPX (Homeodomain-only protein) gene has various synonyms including HOD, HOP, OB1, LAGY and NECC1. The protein encoded by this gene is an unusual homeodomain protein that lacks certain conserved residues required for DNA binding. HOPX has diverse effects on cardiac growth. Manipulation of Hopx function in murine models is associated with cardiac hypertrophy, dilation and fibrosis. HOPX protein acts as an antagonist to the serum response factor (SRF), which regulates the opposing processes of cell proliferation and differentiation. Overexpression of HOPX causes cardiac hypertrophy. HOPX protein can inhibit SRF-dependent transcriptional activation by recruiting histone deacetylase (HDAC) activity.

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