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验证数据展示

  • IHC staining of mouse liver using 84316-7-RR (same clone as 84316-7-PBS)

    IHC staining of mouse liver using 84316-7-RR (same clone as 84316-7-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 84316-7-RR (HNF4A antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84316-7-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 84316-7-RR (same clone as 84316-7-PBS)

    IF Staining of HepG2 using 84316-7-RR (same clone as 84316-7-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using HNF4A antibody (84316-7-RR, Clone: 241593A2 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84316-7-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84316-7-RR

    Affinity and Kinetic Characterization of 84316-7-RR

    Biolayer interferometry (BLl) kinetic assays of 84316-7-RR against Human HNF4A were performed. The affinity constant is 0.275 nM.

HNF4A Recombinant monoclonal antibody, PBS Only

HNF4A Uni-rAb® Recombinant Antibody for IHC, IF/ICC, Indirect ELISA
Cat No. 84316-7-PBS

产品说明书

CloneNo. 241593A2

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, IF/ICC, Indirect ELISA

别名

241593A2, Hepatocyte nuclear factor 4-alpha, HNF 4 alpha, HNF4, HNF4a7

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84316-7-PBS targets HNF4A in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag24647

Product name: Recombinant human HNF4A protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-350 aa of BC137539

Sequence: MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 hepatocyte nuclear factor 4, alpha
别名 241593A2, Hepatocyte nuclear factor 4-alpha, HNF 4 alpha, HNF4, HNF4a7
计算分子量 53 kDa
GenBank蛋白编号BC137539
基因名称 HNF4A
Gene ID (NCBI) 3172
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP41235
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

HNF4A (Hepatocyte nuclear factor 4 α) is highly conserved between humans and mice. Using conditional knockouts, epithelial HNF4A is indispensable for protecting against acute chemical-induced colitis and spontaneous colonic inflammation in aged animals (PMID:35792863). Moreover, reduced expression of HNF4A has been reported in liver fibrosis and viral vector-mediated HNF4A restoration has previously been demonstrated to reverse features of chronic liver injury. Therefore, HNF4A has been suggested as a therapeutic target for the treatment of liver fibrosis (PMID:34453962).

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