×
Use Able AI chat for product recommendations

验证数据展示

  • IHC staining of human liver cancer using 13533-1-AP (same clone as 13533-1-PBS)

    IHC staining of human liver cancer using 13533-1-AP (same clone as 13533-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 13533-1-AP (HMGCR antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13533-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 13533-1-AP (same clone as 13533-1-PBS)

    IHC staining of human liver cancer using 13533-1-AP (same clone as 13533-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 13533-1-AP (HMGCR antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13533-1-PBS in a different storage buffer formulation.

  • IP experiment of HeLa using 13533-1-AP (same clone as 13533-1-PBS)

    IP experiment of HeLa using 13533-1-AP (same clone as 13533-1-PBS)

    IP result of anti-HMGCR (IP:13533-1-AP, 4ug; Detection:13533-1-AP 1:500) with HeLa cells lysate 960 ug. This data was developed using the same antibody clone with 13533-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

HMGCR Polyclonal antibody, PBS Only

HMGCR Polyclonal Antibody for IHC, IP, Indirect ELISA
Cat No. 13533-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

IHC, IP, Indirect ELISA

别名

EC:1.1.1.34, HMG CoA reductase, HMG-CoA reductase

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

点击咨询售前客服

点击咨询售后客服

产品信息

13533-1-PBS targets HMGCR in IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag4444

Product name: Recombinant human HMGCR protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 536-835 aa of BC033692

Sequence: TRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
别名 EC:1.1.1.34, HMG CoA reductase, HMG-CoA reductase
计算分子量 888 aa, 95 kDa
GenBank蛋白编号BC033692
基因名称 HMGCR
Gene ID (NCBI) 3156
RRIDAB_2877957
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP04035
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

HMGCR(3-hydroxy-3-methylglutaryl-coenzyme A reductase) is also named as HMG-CoA reductase and belongs to the HMG-CoA reductase family. This protein exists as a 97-kDa glycoprotein in the endoplasmic reticulum (ER) and is the rate-determining enzyme of the biosynthesis pathway(PMID:15830340).The ectopic expression of either full-length HMGCR or its novel splice variant promotes dysregulation of the MVA pathway. And the ectopic expression of cHMGCR-FL(60 kDa) and cHMGCR-D13(55 kDa) can be detected in HepG2 cells(PMID:20696928).This protein is also can exsit as a oligomer(PMID:20696928).

||
New chat

Able™

正在加载，请稍候...