验证数据展示
产品信息
33973-1-PBS targets HICE1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, IHC, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag40571 Product name: Recombinant human HICE1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 118-284 aa of BC010176 Sequence: DVGDSEENVQVLDLLSELKDVTAKKDLELRRSFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVPPSLSRSGRDLS 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | HEC1/NDC80 interacting, centrosome associated 1 |
| 别名 | HAUS augmin-like complex subunit 8, HAUS8, HEC1/NDC80-interacting centrosome-associated protein 1, Sarcoma antigen NY-SAR-48 |
| 计算分子量 | 410 aa, 45 kDa |
| 观测分子量 | 38kDa, 45kDa |
| GenBank蛋白编号 | BC010176 |
| 基因名称 | HICE1 |
| Gene ID (NCBI) | 93323 |
| RRID | AB_3743129 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q9BT25 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The HICE1 protein (also known as HAUS8) is an important member of the HICE (Hippo pathway components-enriched) family. Hice1 shows distinct cytoplasmic localization and associates with interphase centrosomes and mitotic spindles, preferentially at the spindle pole vicinity. It primarily serves as a core component of the STRIPAK complex (Striatin-interacting phosphatase and kinase complex), where it inhibits the activity of the key kinases MST1/2 in the Hippo signaling pathway by regulating their dephosphorylation, thereby playing a critical role in organ size control, tissue homeostasis maintenance, and cell proliferation and apoptosis.
