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HDAC-IN-7

HDAC-IN-7 是 Tucidinostat (Chidamide) 的类似物，是一种 HDAC 抑制剂。HDAC-IN-7 通过抑制组蛋白 H3 的乙酰化作用，诱导人类结肠癌细胞系的凋亡[1]。

CAS号

743420-02-2

分子式

C22H19FN4O2

主要靶点

HDAC

仅限科研使用

Cat No : CM04401

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Synonyms

西达本胺杂质|CS055|CS055|CS-055|CS 055|Chidamide impurity|HDACIN7|HDAC-IN-7|HDAC8|HDAC3|HDAC2|HDAC IN 7|HDAC1|HDAC|HBI8000|HBI 8000|HBI-8000|HBI-8000

验证数据展示

  • CAS No.: 743420-02-2

    HDAC-IN-7
    CAS#: 743420-02-2

产品信息

HDAC-IN-7, an analogue of Tucidinostat (Chidamide), is a HDAC inhibitor. HDAC-IN-7 inhibits acetylation of histone protein H3 and induces apoptosis in human colon cancer cell lines[1].

CAS号 743420-02-2
分子式 C22H19FN4O2
主要靶点 HDAC
主要通路 DNA 损伤和修复|表观遗传
分子量 390.41
纯度 97.64%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
别名 西达本胺杂质|CS055|CS055|CS-055|CS 055|Chidamide impurity|HDACIN7|HDAC-IN-7|HDAC8|HDAC3|HDAC2|HDAC IN 7|HDAC1|HDAC|HBI8000|HBI 8000|HBI-8000|HBI-8000

靶点活性

HDAC11:432 nM|HDAC2:160nM|HDAC10:78 nM|HDAC8:733nM|HDAC1:95nM|HDAC3:67nM

溶解度

10% DMSO+90% Saline:6 mg/mL (15.37 mM);DMSO:60 mg/mL (153.68 mM)

参考文献

1.Liu L, et al. A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells. Biochem Biophys Res Commun. 2010 Feb 5;392(2):190-5.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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