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验证数据展示

  • WB analysis using 29989-1-AP (same clone as 29989-1-PBS)

    WB analysis using 29989-1-AP (same clone as 29989-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29989-1-AP (GPR37 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29989-1-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 29989-1-AP (same clone as 29989-1-PBS)

    IHC staining of rat brain using 29989-1-AP (same clone as 29989-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 29989-1-AP (GPR37/Pael-R antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29989-1-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 29989-1-AP (same clone as 29989-1-PBS)

    IHC staining of rat brain using 29989-1-AP (same clone as 29989-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 29989-1-AP (GPR37/Pael-R antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29989-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

GPR37/Pael-R Polyclonal antibody, PBS Only

GPR37/Pael-R Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 29989-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

GPR37, Pael-R, EDNRBL, Endothelin B receptor-like protein 1, ETBR LP 1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

29989-1-PBS targets GPR37/Pael-R in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag32431

Product name: Recombinant human GPR37 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 34-180 aa of BC040007

Sequence: SRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 G protein-coupled receptor 37 (endothelin receptor type B-like)
别名 GPR37, Pael-R, EDNRBL, Endothelin B receptor-like protein 1, ETBR LP 1
计算分子量 67 kDa
观测分子量 67 kDa
GenBank蛋白编号BC040007
基因名称 GPR37
Gene ID (NCBI) 2861
RRIDAB_2935493
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO15354
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The orphan G protein-coupled receptor GPR37, also known as PAELR (parkin-associated endothelin receptor-like receptor) or ETBR-LP-1 (endothelin B receptor-like protein 1), is a 613 aa, multi-pass membrane protein predominantly expressed in the brain. It is a substrate of parkin (PARK2). When overexpressed in cells, GPR37 tends to become insoluble, unfolded, and ubiquitinated in vivo. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (JPD).

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