×
Use Able AI chat for product recommendations

验证数据展示

  • WB analysis using 20791-1-AP (same clone as 20791-1-PBS)

    WB analysis using 20791-1-AP (same clone as 20791-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20791-1-AP (GPR172B antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20791-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse testis using 20791-1-AP (same clone as 20791-1-PBS)

    IHC staining of mouse testis using 20791-1-AP (same clone as 20791-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 20791-1-AP (GPR172B antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20791-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse testis using 20791-1-AP (same clone as 20791-1-PBS)

    IHC staining of mouse testis using 20791-1-AP (same clone as 20791-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 20791-1-AP (GPR172B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20791-1-PBS in a different storage buffer formulation.

GPR172B Polyclonal antibody, PBS Only

GPR172B Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 20791-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

GPCR42, hRFT1, PAR2, PERV A receptor 2, Protein GPR172B

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

点击咨询售前客服

点击咨询售后客服

产品信息

20791-1-PBS targets GPR172B in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag14525

Product name: Recombinant human GPR172B protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 201-290 aa of BC060810

Sequence: TALLVTSAAAFRGLLLLLPSLPSVTTGGSGPELQLGSPGAEEEEKEEEEALPLQEPPSQAAGTIPGPDPEVHQLFSAHGAFLLGLMAFTS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 G protein-coupled receptor 172B
别名 GPCR42, hRFT1, PAR2, PERV A receptor 2, Protein GPR172B
计算分子量 448 aa, 46 kDa
观测分子量50 kDa
GenBank蛋白编号BC060810
基因名称 GPR172B
Gene ID (NCBI) 55065
RRIDAB_3742004
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9NWF4
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GPR172B, also known as solute carrier family 52 member 1 (SLC52A1) or riboflavin transporter 1 (RFT1), is a G protein-coupled receptor (GPCR) that plays a significant role in the transport of riboflavin, a vital component for the production of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). GPR172B plays a role in cellular aging. Knockdown of GPR172B promotes senescence induced by DNA damage in both tumor and normal cells. The anti-senescence effect of GPR172B is dependent on its riboflavin transport activity, which leads to the activation of mitochondrial membrane potential (MMP) mediated by mitochondrial electron transport chain complex II, ultimately inhibiting the AMPK-p53 pathway, a central mediator of senescence-associated with mitochondrial dysfunction.

||
New chat

Able™

正在加载，请稍候...