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验证数据展示

  • IHC staining of mouse liver using 16334-1-AP (same clone as 16334-1-PBS)

    IHC staining of mouse liver using 16334-1-AP (same clone as 16334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 16334-1-AP (GPR146 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16334-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 16334-1-AP (same clone as 16334-1-PBS)

    IHC staining of mouse kidney using 16334-1-AP (same clone as 16334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 16334-1-AP (GPR146 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16334-1-PBS in a different storage buffer formulation.

GPR146 Polyclonal antibody, PBS Only

GPR146 Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 16334-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

16334-1-PBS targets GPR146 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag9456

Product name: Recombinant human GPR146 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 211-333 aa of BC014241

Sequence: SRVRREDTPLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 G protein-coupled receptor 146
别名
计算分子量 333 aa, 37 kDa
GenBank蛋白编号BC014241
基因名称 GPR146
Gene ID (NCBI) 115330
RRIDAB_3669240
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96CH1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

As a member of GPCRs, GPR146 (G protein-coupled receptor 146) was initially discovered as a c-peptide signal body. GPR146 may act as a c peptide receptor to interact with proinsulin c-peptide to regulate insulin levels (PMID: 37926274). Mechanically, GPR146 induces hepatic sterol regulatory element binding protein 2 (SREBP2) via the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, consequently resulting in hepatic low-density lipoprotein (VLDL) secretion (PMID: 32491159).

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