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验证数据展示

  • WB analysis using 26122-1-AP (same clone as 26122-1-PBS)

    WB analysis using 26122-1-AP (same clone as 26122-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 26122-1-AP (GPM6B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26122-1-PBS in a different storage buffer formulation.

  • IP experiment of rat brain using 26122-1-AP (same clone as 26122-1-PBS)

    IP experiment of rat brain using 26122-1-AP (same clone as 26122-1-PBS)

    IP result of anti-GPM6B (IP:26122-1-AP, 4ug; Detection:26122-1-AP 1:1000) with rat brain tissue lysate 1720 ug. This data was developed using the same antibody clone with 26122-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 26122-1-AP (same clone as 26122-1-PBS)

    IHC staining of mouse brain using 26122-1-AP (same clone as 26122-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26122-1-AP (GPM6B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26122-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 26122-1-AP (same clone as 26122-1-PBS)

    IHC staining of mouse brain using 26122-1-AP (same clone as 26122-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26122-1-AP (GPM6B antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26122-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 26122-1-AP (same clone as 26122-1-PBS)

    IF Staining of mouse brain using 26122-1-AP (same clone as 26122-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using GPM6B antibody (26122-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 26122-1-PBS in a different storage buffer formulation.

GPM6B Polyclonal antibody, PBS Only

GPM6B Polyclonal Antibody for WB, IHC, IF-P, IP, Indirect ELISA
Cat No. 26122-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF-P, IP, Indirect ELISA

别名

glycoprotein M6B, M6B

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

26122-1-PBS targets GPM6B in WB, IHC, IF-P, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF-P, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag23507

Product name: Recombinant human GPM6B protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-62 aa of BC047295

Sequence: MKPAMETAAEENTEQSQERKVNSRAEMEIGRYHWMYPGSKNHQYHPVPTLGDRASPLSSPGC

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 glycoprotein M6B
别名 glycoprotein M6B, M6B
观测分子量 27-36 kDa
GenBank蛋白编号BC047295
基因名称 GPM6B
Gene ID (NCBI) 2824
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ13491
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GPM6B (Glycoprotein M6B) is a highly conserved, multi-pass transmembrane glycoprotein encoded by the GPM6B gene on human chromosome Xp22.2. As a member of the proteolipid protein family, it is predominantly expressed in the central nervous system (in neurons and oligodendrocytes) and is involved in key processes such as myelination, regulation of serotonin transporter (SERT) trafficking, and actin cytoskeleton maintenance. Beyond neural functions, GPM6B also promotes bone formation by regulating osteoblast mineralization and influences smooth muscle cell differentiation via the TGF‑beta‑Smad2/3 pathway. Subcellularly, it localizes to the plasma membrane and lipid rafts. Genetic variations in GPM6B have been associated with several disorders, including Pelizaeus‑Merzbacher disease, major depressive disorder, and osteoarthritis.

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