Golgi transport 1B (GOLT1B) is a member of the GOT1 family, and abnormal expressions of proteins in this family are associated with GA membrane trafficking disorders and cellular malignant behaviors. The GOT1 family consists of two primary members, GOLT1A and GOLT1B. High expression of GOLT1A has been correlated with poor prognosis and resistance to endocrine therapy in breast cancer. GOLT1B is located primarily in early Golgi cisternae, the absence of which induces a substantial reduction in the endoplasmic reticulum (ER)-Golgi transport efficiency. The amplification of GOLT1B is correlated with poor prognosis in lung cancer. GOLT1B contributes to epithelial-mesenchymal transition (EMT) in colorectal cancer (CRC) by activating WNT signaling, influencing the secretion of interferon (IFN)-γ, and apoptosis of tumor-infiltrating T lymphocytes. (PMID: 38130634)