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验证数据展示

  • WB analysis using 17101-1-AP (same clone as 17101-1-PBS)

    WB analysis using 17101-1-AP (same clone as 17101-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17101-1-AP (GCNT3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17101-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach cancer using 17101-1-AP (same clone as 17101-1-PBS)

    IHC staining of human stomach cancer using 17101-1-AP (same clone as 17101-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 17101-1-AP (GCNT3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17101-1-PBS in a different storage buffer formulation.

GCNT3 Polyclonal antibody, PBS Only

GCNT3 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 17101-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, C2/4GnT, C2GnT mucin type, C2GnT-M, C2GnT-mucin type

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

17101-1-PBS targets GCNT3 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag10765

Product name: Recombinant human GCNT3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-438 aa of BC017032

Sequence: MVQWKRLCQLHYLWALGCYMLLATVALKLSFRLKCDSDHLGLESRESQSQYCRNILYNFLKLPAKRSINCSGVTRGDQEAVLQAILNNLEVKKKREPFTDTHYLSLTRDCEHFKAERKFIQFPLSKEEVEFPIAYSMVIHEKIENFERLLRAVYAPQNIYCVHVDEKSPETFKEAVKAIISCFPNVFIASKLVRVVYASWSRVQADLNCMEDLLQSSVPWKYFLNTCGTDFPIKSNAEMVQALKMLNGRNSMESEVPPKHKETRWKYHFEVVRDTLHLTNKKKDPPPYNLTMFTGNAYIVASRDFVQHVLKNPKSQQLIEWVKDTYSPDEHLWATLQRARWMPGSVPNHPKYDISDMTSIARLVKWQGHEGDIDKGAPYAPCSGIHQRAICVYGAGDLNWMLQNHHLLANKFDPKVDDNALQCLEEYLRYKAIYGTEL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 glucosaminyl (N-acetyl) transferase 3, mucin type
别名 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, C2/4GnT, C2GnT mucin type, C2GnT-M, C2GnT-mucin type
计算分子量 438 aa, 51 kDa
观测分子量51 kDa
GenBank蛋白编号BC017032
基因名称 GCNT3
Gene ID (NCBI) 9245
RRIDAB_3741904
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO95395
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Mucin-type core 2 1,6-N-acetylglucosaminyltransferase enzyme (C2GnT-M), encoded by the GCNT3 gene, has been reported to be altered in tumours and to possess tumour suppressor properties.GCNT3 is markedly expressed in both lung cancer tissues and BRCA tissues, and high GCNT3 levels correlate with poorer outcomes in patients undergoing radiotherapy (PMID: 25466507, 39697709). Elevated levels of GCNT3 promoted cell growth, migration, cell cycle development, and invasion, in addition to EMT, while suppressing apoptosis (PMID: 38789846).

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