CoraLite® Plus 488 Anti-Mouse Foxp3 (3G3)

Foxp3 Monoclonal Antibody for FC (Intra)
Cat No. CL488-65089

产品说明书

CloneNo. 3G3

宿主/亚型

Mouse / IgG1, kappa

种属反应性

Mouse and More (1)

应用

FC (Intra)

forkhead box P3, Foxp3, JM2, scurfin, sf

缓冲液配方:  PBS and Azide
PBS and Azide
规格价格库存


经过测试的应用

Positive FC (Intra) detected inmouse splenocytes
Positive FC detected inmouse splenocytes
For other applications, we recommend the unconjugated version of this antibody, 65089-1-Ig

推荐稀释比

应用推荐稀释比
Flow Cytometry (FC) (INTRA)FC (INTRA) : 0.06 ug per 10^6 cells in 100 μl suspension
Flow Cytometry (FC)FC :
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-65089 targets Foxp3 in FC (Intra) applications and shows reactivity with Mouse samples.

经测试应用 FC (Intra) Application Description
文献引用应用FC (Intra)
经测试反应性 Mouse
文献引用反应性mouse
免疫原 N/A 种属同源性预测
宿主/亚型 Mouse / IgG1, kappa
抗体类别 Monoclonal
产品类型 Antibody
全称 forkhead box P3
别名 forkhead box P3, Foxp3, JM2, scurfin, sf
GenBank蛋白编号BC132333
基因名称 Foxp3
Gene ID (NCBI) 20371
RRIDAB_2919258
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式 Liquid
纯化方式Affinity purification
储存缓冲液 PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3.
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

Foxp3 (forkhead box P3), also named as IPEX, JM2 and scurfin, is a member of the forkhead transcription factor family and is essential for normal immune homeostasis (PMID: 11138001; 20429413). Foxp3 is specifically expressed in CD4+ CD25+ regulatory T cells and is crucial for their development and suppressive activity (PMID: 12612578; 12612581). In scurfy mouse, disruption of Foxp3 results in the fatal lymphoproliferative disorder attributed to the lack of an immune-suppressive component in the immune system (PMID: 25683611; 11138001). Similar to mice, genetic defects in human Foxp3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) which also known as X-linked autoimmunity-immunodeficiency syndrome (PMID: 11137993).

实验方案

Product Specific Protocols
FC protocol for CL Plus 488 Foxp3 antibody CL488-65089Download protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
mouseFC (Intra)

Adv Sci (Weinh)

Cancer-Associated Fibroblast-Induced Remodeling of Tumor Microenvironment in Recurrent Bladder Cancer

Authors - Ting Liang
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