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验证数据展示

  • WB analysis using 16190-1-AP (same clone as 16190-1-PBS)

    WB analysis using 16190-1-AP (same clone as 16190-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 16190-1-AP (FcRn-Specific antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

  • WB analysis of THP-1 using 16190-1-AP (same clone as 16190-1-PBS)

    WB analysis of THP-1 using 16190-1-AP (same clone as 16190-1-PBS)

    WB result of FcRn-Specific antibody (16190-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-FcRn-Specific transfected THP-1 cells. This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

    IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with FCGRT/FCRN antibody included
  • IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

    IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with FCGRT/FCRN antibody included
  • Featured Product
  • KD/KO Validated

FcRn-Specific Polyclonal antibody, PBS Only

FcRn-Specific Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 16190-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

FCGRT, FCRN, Neonatal Fc receptor

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy® FCGRT/FCRN Ready-To-Use IHC Kit. FCGRT/FCRN primary antibody included.

产品信息

16190-1-PBS targets FcRn-Specific in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 Fc fragment of IgG, receptor, transporter, alpha
别名 FCGRT, FCRN, Neonatal Fc receptor
计算分子量 40 kDa
观测分子量40 kDa
GenBank蛋白编号NM_004107
基因名称 FcRn
Gene ID (NCBI) 2217
RRIDAB_2231751
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP55899
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The neonatal Fc receptor for IgG (FcRn) is a membrane-associated receptor which acts as a key determinant of IgG homeostasis. FcRn is similar in structure to major histocompatibility class I molecules. It is a heterodimer composed of a alpha chain associated with β2-microglobulin. FcRn transfers IgG from the mother to the fetus across the placenta and the proximal small intestine. In addition, throughout life, FcRn protects IgG from degradation and thus regulates the serum half-life of IgG (PMID: 17703228).

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