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验证数据展示

  • IHC staining of mouse heart using 31744-1-AP (same clone as 31744-1-PBS)

    IHC staining of mouse heart using 31744-1-AP (same clone as 31744-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 31744-1-AP (FHOD3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31744-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse heart using 31744-1-AP (same clone as 31744-1-PBS)

    IF Staining of mouse heart using 31744-1-AP (same clone as 31744-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse heart tissue using FHOD3 antibody (31744-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31744-1-PBS in a different storage buffer formulation.

FHOD3 Polyclonal antibody, PBS Only

FHOD3 Polyclonal Antibody for IHC, IF-P, Indirect ELISA
Cat No. 31744-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, IF-P, Indirect ELISA

别名

CMH28, FHOS2, hFHOS2, KIAA1695

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

31744-1-PBS targets FHOD3 in IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag36247

Product name: Recombinant human FHOD3 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 650-825 aa of BC157093

Sequence: RTTGLWPAGVQDAGVNGQCGDILTNKRFMLDMLYAHNRKSPDDEEKGDGEAGRTQQEAEAVASLATRISTLQANSQTQDESVRRVDVGCLDNRGSVKAFAEKFNSGDLGRGSISPDAEPNDKVPETAPVQPKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGHRE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 formin homology 2 domain containing 3
别名 CMH28, FHOS2, hFHOS2, KIAA1695
GenBank蛋白编号BC157093
基因名称 FHOD3
Gene ID (NCBI) 80206
RRIDAB_3742470
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ2V2M9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FHOD3, also known as FHOS2 or Formactin2, was an important member of Formin homology proteins. FHOD3 plays a crucial role in organizing the cytoskeleton, primarily by regulating actin filament polymerization within cardiomyocytes, which is essential for heart muscle structure and function. Mutations in this gene are associated with familial cardiomyopathies, including dilated cardiomyopathy (DCM), and its protein levels are altered in hypertrophic cardiomyopathy (HCM). FHOD3 is expressed abundantly in the heart (PMID: 32447646, PMID: 33251537).

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