验证数据展示
产品信息
33265-1-PBS targets FBXL6 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag36604 Product name: Recombinant human FBXL6 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-182 aa of NM_012162.3 Sequence: MAAPASRQVRRRARAAPRPRSAEDWWWDRLAPRGSGYHLLQSDSMLLVLSEPGPARPRAQRRASRRTPRQPPRGPSAAAKPKAGLRSEAAAAPAPAPAPTPTPEEGPDAGWGDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAKGGVKAEKKLL 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | F-box and leucine-rich repeat protein 6 |
| 别名 | FBL6, FBL6A, F-box and leucine-rich repeat protein 6, F-box protein FBL6, F-box/LRR-repeat protein 6 |
| 计算分子量 | 59kDa，539aa |
| 观测分子量 | 60 kDa |
| GenBank蛋白编号 | NM_012162.3 |
| 基因名称 | FBXL6 |
| Gene ID (NCBI) | 26233 |
| RRID | AB_3742921 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q8N531 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
FBXL6 is an F-box/LRR-type E3 ubiquitin ligase that serves as the substrate-recognition subunit of the SCF complex. It stabilizes HSP90AA1 via K63-linked ubiquitination to activate c-MYC and drive hepatocellular carcinoma progression, while also degrading defective mitochondrial ribosomal proteins to preserve mitochondrial proteostasis. Its overexpression correlates with poor prognosis in renal and colorectal cancers and can promote cell proliferation by down-regulating RPL11 to activate the MDM2-p53 axis.
