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验证数据展示

  • WB analysis using 20949-1-AP (same clone as 20949-1-PBS)

    WB analysis using 20949-1-AP (same clone as 20949-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 20949-1-AP (FBXL20 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20949-1-PBS in a different storage buffer formulation.

  • IF Staining of MCF-7 using 20949-1-AP (same clone as 20949-1-PBS)

    IF Staining of MCF-7 using 20949-1-AP (same clone as 20949-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using FBXL20 antibody (20949-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 20949-1-PBS in a different storage buffer formulation.

FBXL20 Polyclonal antibody, PBS Only

FBXL20 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 20949-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

Fbl2, Fbl20

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

20949-1-PBS targets FBXL20 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag15071

Product name: Recombinant human FBXL20 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 80-436 aa of BC007557

Sequence: RVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 F-box and leucine-rich repeat protein 20
别名 Fbl2, Fbl20
计算分子量 436 aa, 48 kDa
观测分子量48 kDa
GenBank蛋白编号BC007557
基因名称 FBXL20
Gene ID (NCBI) 84961
RRIDAB_3742010
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ96IG2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FBXL20 (F-box and leucine-rich repeat protein 20) is a member of the F-box protein family, which plays a crucial role in the ubiquitin-proteasome system. FBXL20 acts as a substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex, targeting specific proteins for ubiquitination and subsequent degradation. This protein is involved in cell cycle regulation, signal transduction, and maintenance of protein homeostasis. Abnormal expression of FBXL20 has been implicated in various diseases, including cancer and neurodegenerative disorders. Research also suggests that FBXL20 may regulate the degradation of 4-1BB, an important immune stimulator, through ubiquitination. (PMID: 25593308, PMID: 27502938, PMID: 35112462)

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