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验证数据展示

  • WB analysis using 84807-4-RR (same clone as 84807-4-PBS)

    WB analysis using 84807-4-RR (same clone as 84807-4-PBS)

    bEnd.3 cells were subjected to SDS PAGE followed by western blot with 84807-4-RR (Endoglin/CD105 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84807-4-PBS in a different storage buffer formulation.

  • IF Staining of bEnd.3 using 84807-4-RR (same clone as 84807-4-PBS)

    IF Staining of bEnd.3 using 84807-4-RR (same clone as 84807-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed bEnd.3 cells using Endoglin/CD105 antibody (84807-4-RR, Clone: 242305G3 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84807-4-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 84807-4-RR (same clone as 84807-4-PBS)

    IHC staining of mouse kidney using 84807-4-RR (same clone as 84807-4-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 84807-4-RR (Endoglin/CD105 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84807-4-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 84807-4-RR (same clone as 84807-4-PBS)

    IHC staining of mouse kidney using 84807-4-RR (same clone as 84807-4-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 84807-4-RR (Endoglin/CD105 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84807-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84807-4-RR

    Affinity and Kinetic Characterization of 84807-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84807-4-RR against Mouse Endoglin/CD105 were performed. The affinity constant is 0.888 nM.

Mouse Endoglin/CD105 Recombinant monoclonal antibody, PBS Only

Endoglin/CD105 Uni-rAb® Recombinant Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 84807-4-PBS

产品说明书

CloneNo. 242305G3

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

CD105, 242305G3, S endoglin, Eng, endoglin

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84807-4-PBS targets Endoglin/CD105 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with mouse samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 mouse
免疫原

Recombinant protein

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 endoglin
别名 CD105, 242305G3, S endoglin, Eng, endoglin
计算分子量70 kDa
观测分子量85-90 kDa
GenBank蛋白编号NM_007932.2
基因名称 CD105
Gene ID (NCBI) 13805
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ63961
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodeling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)

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