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验证数据展示

  • WB analysis using 11721-1-AP (same clone as 11721-1-PBS)

    WB analysis using 11721-1-AP (same clone as 11721-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11721-1-AP (ETV3 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11721-1-PBS in a different storage buffer formulation.

  • IP experiment of HepG2 using 11721-1-AP (same clone as 11721-1-PBS)

    IP experiment of HepG2 using 11721-1-AP (same clone as 11721-1-PBS)

    IP result of anti-ETV3 (IP:11721-1-AP, 4ug; Detection:11721-1-AP 1:500) with HepG2 cells lysate 1440 ug. This data was developed using the same antibody clone with 11721-1-PBS in a different storage buffer formulation.

ETV3 Polyclonal antibody, PBS Only

ETV3 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 11721-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IP, Indirect ELISA

别名

ets variant 3, ETV 3, PE-1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

11721-1-PBS targets ETV3 in WB, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag2301

Product name: Recombinant human ETV3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-143 aa of BC022868

Sequence: MKAGCSIVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGKIQTLLVGN

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ets variant 3
别名 ets variant 3, ETV 3, PE-1
计算分子量 512 aa, 57 kDa
观测分子量57 kDa
GenBank蛋白编号BC022868
基因名称 ETV3
Gene ID (NCBI) 2117
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP41162
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ETV3 is a transcriptional repressor that belongs to the ETS family of transcription factors, which bind a common DNA sequence core motif (GGAA) via their ETS domains. ETV3 is preferentially expressed in mature DC including tissue-derived migratory DC (migDC) and facilitates their homeostatic maturation and CCR7-dependent migration. Phosphorylation of ETV3 regulated transcription by preventing its binding to DNA at promoters for several thousand genes, including some involved in negative feedback regulation of itself and of upstream signals (PMID: 36543959, 41678619). Western and IP analysis detected the specific band with an apparent MW of 57 kDa.

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