验证数据展示
产品信息
32571-1-PBS targets EPS8L3 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag38525 Product name: Recombinant human EPS8L3 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 408-593 aa of NM_001319952.1 Sequence: PVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP* 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | EPS8-like 3 |
| 别名 | Epidermal growth factor receptor kinase substrate 8-like protein 3, Epidermal growth factor receptor pathway substrate 8-related protein 3, EPS8 Signaling Adaptor L3, EPS8-like protein 3, EPS8R3 |
| 计算分子量 | 67kDa，593aa |
| 观测分子量 | 65 kDa |
| GenBank蛋白编号 | NM_001319952.1 |
| 基因名称 | EPS8L3 |
| Gene ID (NCBI) | 79574 |
| RRID | AB_3742659 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q8TE67 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
EPS8L3 (epidermal growth factor receptor kinase substrate 8-like protein 3) is a member of the EPS8 family, encoding a protein associated with the epidermal growth factor receptor (EGFR) signaling pathway. Studies have shown that EPS8L3 is highly expressed in a variety of tumors, such as hepatocellular carcinoma (HCC), pancreatic cancer, and gastric cancer, and is closely associated with tumor proliferation, migration, and invasive ability. It promotes tumor cell proliferation and inhibits apoptosis by activating GSK3β and PI3K/AKT/mTOR signaling pathways. In addition, high expression of EPS8L3 is associated with poor prognosis in tumor patients and may serve as a biomarker for tumor diagnosis and prognostic assessment. Due to its important role in tumors, EPS8L3 is considered a potential therapeutic target, and its inhibition may enhance the efficacy of multi-target kinase inhibitors.
