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验证数据展示

  • WB analysis using 32571-1-AP

    WB analysis using 32571-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 32571-1-AP (EPS8L3 antibody) at dilution of 1:40000 incubated at room temperature for 1.5 hours.

EPS8L3 Polyclonal antibody

EPS8L3 Polyclonal Antibody for WB, ELISA
Cat No. 32571-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, ELISA

别名

Epidermal growth factor receptor kinase substrate 8-like protein 3, Epidermal growth factor receptor pathway substrate 8-related protein 3, EPS8 Signaling Adaptor L3, EPS8-like protein 3, EPS8R3

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格价格库存

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经过测试的应用

Positive WB detected inHepG2 cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

32571-1-AP targets EPS8L3 in WB, ELISA applications and shows reactivity with human samples.

经测试应用 WB, ELISA Application Description
经测试反应性 human
免疫原 EPS8L3 fusion protein Ag38525 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 EPS8-like 3
别名 Epidermal growth factor receptor kinase substrate 8-like protein 3, Epidermal growth factor receptor pathway substrate 8-related protein 3, EPS8 Signaling Adaptor L3, EPS8-like protein 3, EPS8R3
计算分子量67kDa，593aa
观测分子量65 kDa
GenBank蛋白编号NM_001319952.1
基因名称 EPS8L3
Gene ID (NCBI) 79574
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ8TE67
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

EPS8L3 (epidermal growth factor receptor kinase substrate 8-like protein 3) is a member of the EPS8 family, encoding a protein associated with the epidermal growth factor receptor (EGFR) signaling pathway. Studies have shown that EPS8L3 is highly expressed in a variety of tumors, such as hepatocellular carcinoma (HCC), pancreatic cancer, and gastric cancer, and is closely associated with tumor proliferation, migration, and invasive ability. It promotes tumor cell proliferation and inhibits apoptosis by activating GSK3β and PI3K/AKT/mTOR signaling pathways. In addition, high expression of EPS8L3 is associated with poor prognosis in tumor patients and may serve as a biomarker for tumor diagnosis and prognostic assessment. Due to its important role in tumors, EPS8L3 is considered a potential therapeutic target, and its inhibition may enhance the efficacy of multi-target kinase inhibitors.

实验方案

Product Specific Protocols
WB protocol for EPS8L3 antibody 32571-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols