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验证数据展示

  • WB analysis using 20883-1-AP (same clone as 20883-1-PBS)

    WB analysis using 20883-1-AP (same clone as 20883-1-PBS)

    HT-29 cells were subjected to SDS PAGE followed by western blot with 20883-1-AP (EPHB4 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20883-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 20883-1-AP (same clone as 20883-1-PBS)

    IHC staining of human lung cancer using 20883-1-AP (same clone as 20883-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 20883-1-AP (EPHB4 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20883-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with EPHB4 antibody included
  • IF Staining of HT-29 using 20883-1-AP (same clone as 20883-1-PBS)

    IF Staining of HT-29 using 20883-1-AP (same clone as 20883-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HT-29 cells using EPHB4 antibody (20883-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 20883-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 20883-1-AP (same clone as 20883-1-PBS)

    IHC staining of human lung cancer using 20883-1-AP (same clone as 20883-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 20883-1-AP (EPHB4 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20883-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with EPHB4 antibody included
  • Featured Product
  • KD/KO Validated

EPHB4 Polyclonal antibody, PBS Only

EPHB4 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 20883-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

EC:2.7.10.1, EPH receptor B4, Ephrin type B receptor 4, Ephrin type-B receptor 4, HTK

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy EPHB4 Ready-To-Use IHC Kit. EPHB4 primary antibody included.

产品信息

20883-1-PBS targets EPHB4 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag10033

Product name: Recombinant human EPHB4 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 639-987 aa of BC052804

Sequence: KKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGGPAPQY

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 EPH receptor B4
别名 EC:2.7.10.1, EPH receptor B4, Ephrin type B receptor 4, Ephrin type-B receptor 4, HTK
计算分子量 987 aa, 108 kDa
观测分子量 110-120 kDa
GenBank蛋白编号BC052804
基因名称 EPHB4
Gene ID (NCBI) 2050
RRIDAB_10897158
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP54760
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

EPHB4 (Ephrin type-B receptor 4) is a member of the Eph receptor tyrosine kinase family, the largest group of receptor tyrosine kinases. It binds ephrin-B ligands to regulate embryonic vascular development, lymphangiogenesis, and adult angiogenesis. Aberrant EPHB4 signaling promotes tumor progression, metastasis, and therapy resistance in various cancers, including breast, prostate, and colorectal malignancies. As a key regulator of tumor vasculature and the tumor microenvironment, EPHB4 represents an emerging therapeutic target for anti-cancer drug development and a potential prognostic biomarker.

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