验证数据展示
产品信息
28303-1-PBS targets ENPP3/CD203c in WB, Indirect ELISA applications and shows reactivity with human, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, rat |
| 免疫原 |
CatNo: Ag28478 Product name: Recombinant human ENPP3 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 344-512 aa of BC146579 Sequence: VVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPF 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | ectonucleotide pyrophosphatase/phosphodiesterase 3 |
| 别名 | ENPP3, B10, CD203c, E NPP 3, PD IBETA |
| 计算分子量 | 875 aa, 100 kDa |
| 观测分子量 | 120-150 kDa |
| GenBank蛋白编号 | BC146579 |
| 基因名称 | ENPP3 |
| Gene ID (NCBI) | 5169 |
| RRID | AB_3742290 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O14638 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ENPP3/CD203c is part of ectonucleotide pyrophosphatases/phosphodiesterase (ENPP) family and plays a role in various physiological processes. Increased levels of ENPP3 have been observed in conditions, such as clear cell renal cell carcinoma, bile duct carcinoma, and colorectal cancer, positioning ENPP3 as a potential tumor marker (PMID: 38749434). Mice harboring a point mutant of ENPP3 that specifically abolishes its cGAMP hydrolase activity are more resistant to both primary tumor growth and metastasis in certain cancers (PMID: 38149831). High molecular weight band is the glycosylated form of ENPP3 (PMID: 27665743, 30271993)
