验证数据展示
产品信息
85963-1-PBS targets ENPEP in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | ENPEP fusion protein Eg2736 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | glutamyl aminopeptidase (aminopeptidase A) |
别名 | AP A, APA, AP-A, CD249, EAP |
计算分子量 | 109 kDa |
观测分子量 | 140 kDa |
GenBank蛋白编号 | NM_001977.3 |
基因名称 | ENPEP |
Gene ID (NCBI) | 2028 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q07075 |
储存缓冲液 | PBS only, pH 7.3. |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ENPEP is the gene encoding the protein glutamyl aminopeptidase, also known as aminopeptidase A (APA), human kidney differentiation antigen (gp160). A type 2 membrane zinc metalloenzyme, APA is a general-purpose protease that primarily serves to cleave the acidic N-terminal aspartate and glutamyl residues of a variety of peptides, most significantly angiotensin 2 (ANG2, ang1-8), cholecystokinin-8 (CCK8), and neurokinin A. The presence of Ca2+ augments both the enzymatic efficiency and specificity of APA, increasing its selectivity towards the aforementioned acidic amino acids. Conversely, in the absence of calcium, APA can bind a wider range of N-terminal neutral and basic amino acids, some of which are cleaved, while others bind without proteolysis.