验证数据展示
产品信息
66354-1-PBS targets EBI3/IL-27B in WB, Indirect ELISA applications and shows reactivity with human, rat, pig samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, rat, pig |
| 免疫原 | EBI3/IL-27B fusion protein Ag3051 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | Epstein-Barr virus induced 3 |
| 别名 | EBI3, 1F3H10, EBV induced gene 3 protein, EBV-induced gene 3 protein, Epstein Barr virus induced 3 |
| 计算分子量 | 229 aa, 25 kDa |
| 观测分子量 | 34 kDa |
| GenBank蛋白编号 | BC015364 |
| 基因名称 | EBI3 |
| Gene ID (NCBI) | 10148 |
| RRID | AB_2881734 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q14213 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
EBI3, a 34-kDa secreted glycoprotein, is a subunit in 2 distinct heterodimeric cytokines: IL-27 and IL-35. IL-27, composed of p28 (IL-27) and EBI3, can trigger signaling in T cells, B cells, and myeloid cells. IL-35, composed of EBI3 and the ubiquitously expressed p35 subunit of IL-12, is an inhibitory cytokine involved in regulatory T-cell function. EBI3 plays a role in regulating cell-mediated immune responses. (PMID: 8551575; 18033300; 17874423; 21931777)
