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(S,R,S)-AHPC-Me hydrochloride

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein.

CAS号

1948273-03-7

分子式

C23H33ClN4O3S

主要靶点

Ligand for E3 Ligase|Others

仅限科研使用

Cat No : CM01673

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Synonyms

E3 ligase Ligand 1|VHL ligand 2 hydrochloride

验证数据展示

  • CAS No.: 1948273-03-7

    (S,R,S)-AHPC-Me hydrochloride
    CAS#: 1948273-03-7

产品信息

(S,R,S)-AHPC-Me hydrochloride is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein.

CAS号 1948273-03-7
分子式 C23H33ClN4O3S
主要靶点 Ligand for E3 Ligase|Others
主要通路 其他|PROTAC
分子量 481.05
纯度 99.18%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 E3 ligase Ligand 1|VHL ligand 2 hydrochloride

溶解度

DMSO:62 mg/mL(128.88 mM)

参考文献

1.WO/2017/030814A1
2.Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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