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(S,R,S)-AHPC-Me

(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) 是基于 (S,R,S)-AHPC 的的 VHL 配体，可用于募集 von Hippel-Lindau (VHL) 蛋白。它可有效降解去势抵抗性前列腺癌细胞中的 BET 蛋白，DC50<1 nM。它可用于合成 ARV-771。

CAS号

1948273-02-6

分子式

C23H32N4O3S

主要靶点

Ligand for E3 Ligase

仅限科研使用

Cat No : CM01381

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Synonyms

VHL ligand 2|E3 ligase Ligand 1A

验证数据展示

  • CAS No.: 1948273-02-6

    (S,R,S)-AHPC-Me
    CAS#: 1948273-02-6

产品信息

(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

CAS号 1948273-02-6
分子式 C23H32N4O3S
主要靶点 Ligand for E3 Ligase
主要通路 PROTAC
分子量 444.59
纯度 99.86%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 VHL ligand 2|E3 ligase Ligand 1A

参考文献

1.Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.

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