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验证数据展示

  • WB analysis using 20683-1-AP (same clone as 20683-1-PBS)

    WB analysis using 20683-1-AP (same clone as 20683-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20683-1-AP (DOCK3; MOCA antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20683-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 20683-1-AP (same clone as 20683-1-PBS)

    IHC staining of mouse brain using 20683-1-AP (same clone as 20683-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 20683-1-AP (DOCK3; MOCA antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20683-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with DOCK3 antibody included
  • IHC staining of mouse brain using 20683-1-AP (same clone as 20683-1-PBS)

    IHC staining of mouse brain using 20683-1-AP (same clone as 20683-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 20683-1-AP (DOCK3; MOCA antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20683-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with DOCK3 antibody included

DOCK3; MOCA Polyclonal antibody, PBS Only

DOCK3; MOCA Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 20683-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy DOCK3 Ready-To-Use IHC Kit. DOCK3 primary antibody included.

产品信息

20683-1-PBS targets DOCK3; MOCA in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 dedicator of cytokinesis 3
别名
计算分子量 233 kDa
观测分子量 233 kDa
GenBank蛋白编号NM_004947
基因名称 DOCK3
Gene ID (NCBI) 1795
RRIDAB_10696182
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8IZD9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Dedicator of cytokinesis 3 (DOCK3), also named as MOCA and PBP , is a ~180 kDa protein involved in signaling trasduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, thereby promoteing axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.

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