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验证数据展示

  • WB analysis using 24206-1-AP (same clone as 24206-1-PBS)

    WB analysis using 24206-1-AP (same clone as 24206-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24206-1-AP (DNMT1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24206-1-PBS in a different storage buffer formulation.

  • IP experiment of HEK-293 using 24206-1-AP (same clone as 24206-1-PBS)

    IP experiment of HEK-293 using 24206-1-AP (same clone as 24206-1-PBS)

    IP result of anti-DNMT1 (IP:24206-1-AP, 4ug; Detection:24206-1-AP 1:500) with HEK-293 cells lysate 1400 ug. This data was developed using the same antibody clone with 24206-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

DNMT1 Polyclonal antibody, PBS Only

DNMT1 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 24206-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

WB, IP, Indirect ELISA

别名

AIM, CXXC9, CXXC-type zinc finger protein 9, DNA (cytosine-5)-methyltransferase 1, DNMT

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

24206-1-PBS targets DNMT1 in WB, IP, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, IP, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原

CatNo: Ag19116

Product name: Recombinant human DNMT1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1288-1632 aa of BC126227

Sequence: VSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 DNA (cytosine-5-)-methyltransferase 1
别名 AIM, CXXC9, CXXC-type zinc finger protein 9, DNA (cytosine-5)-methyltransferase 1, DNMT
计算分子量 1632 aa, 185 kDa
观测分子量180-200 kDa
GenBank蛋白编号BC126227
基因名称 DNMT1
Gene ID (NCBI) 1786
RRIDAB_2879457
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP26358
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

DNA methylation is a major epigenetic modification that regulates gene expression. DNMT1, the maintenance DNA methylation enzyme, is the primary enzyme responsible for copying methylation patterns after DNA replication. DNMT1 is required for X chromosome inactivation, imprinting, genomic methylation and proper embryonic development. Overexpression of DNMT1 has been reported in various cancers. DNMT1 exists some isoforms with MW 184 kDa and 145 kDa. (PMID: 10753866)

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