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验证数据展示

  • WB analysis of A549 using 14054-1-AP (same clone as 14054-1-PBS)

    WB analysis of A549 using 14054-1-AP (same clone as 14054-1-PBS)

    WB result of DLK/MAP3K12 antibody (14054-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-DLK/MAP3K12 transfected A549 cells. This data was developed using the same antibody clone with 14054-1-PBS in a different storage buffer formulation.

  • WB analysis using 14054-1-AP (same clone as 14054-1-PBS)

    WB analysis using 14054-1-AP (same clone as 14054-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14054-1-AP (DLK/MAP3K12 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14054-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

DLK/MAP3K12 Polyclonal antibody, PBS Only

DLK/MAP3K12 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 14054-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

DLK, MAP3K12, EC:2.7.11.25, Leucine-zipper protein kinase, MAPK-upstream kinase

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

14054-1-PBS targets DLK/MAP3K12 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag4780

Product name: Recombinant human MAP3K12 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 220-567 aa of BC050050

Sequence: CILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGPQLPSLHESHSYSLYIEKYLYKLYIYTYIYIYAPHNQQKDGAVPAVSQARGRLIP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 mitogen-activated protein kinase kinase kinase 12
别名 DLK, MAP3K12, EC:2.7.11.25, Leucine-zipper protein kinase, MAPK-upstream kinase
计算分子量 567 aa, 64 kDa
观测分子量100-110 kDa
GenBank蛋白编号BC050050
基因名称 MAP3K12
Gene ID (NCBI) 7786
RRIDAB_3741851
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ12852
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MAP3K12, also named as DLK ((dual leucine zipper kinase), is a part of a non-canonical MAPK signaling pathway. It has been reported that MAP3K12 can be activated by APOE through a receptor-mediated mechanism. MAP3K12 enhances the AP-1-mediated transcription of APP via a MAP kinase signal transduction pathway composed of MAP2K7, MAPK1/ERK2 and MAPK3/ERK1. MAP3K12 is required for pancreatic beta-cell proliferation during postnatal development and stress-induced JNK signaling in neurons.(PMID: 28111074, 25341110, 32189007)

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