验证数据展示
产品信息
67203-1-PBS targets DCC-Specific in WB, Indirect ELISA applications and shows reactivity with Human, Mouse samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | Human, Mouse |
| 免疫原 | DCC-Specific fusion protein Ag20569 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | deleted in colorectal carcinoma |
| 别名 | Colorectal cancer suppressor, CRC18, CRCR1, DCC, DCC-Specific, IGDCC1, Netrin receptor DCC, Tumor suppressor protein DCC |
| 计算分子量 | 1447 aa, 158 kDa |
| 观测分子量 | 180 kDa |
| GenBank蛋白编号 | NM_005215 |
| 基因名称 | DCC |
| Gene ID (NCBI) | 1630 |
| RRID | AB_2882496 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P43146 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
DCC, also named as IGDCC1, belongs to the immunoglobulin superfamily and DCC family. DCC is a receptor for netrin required for axon guidance. DCC plays a key role in the developing nervous system. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. DCC gene is a tumor suppressor gene. This antibody recognizes endogenous DCC with an apparent molecular weight of 180 kDa. As the predicted molecular mass of DCC is 158 kDa, the slower mobility is likely attributable to post-translational modification, perhaps by glycosylation at potential N-linked glycosylation sites (PMID: 7926722; 8044801).