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验证数据展示

  • WB analysis using 86948-1-RR (same clone as 86948-1-PBS)

    WB analysis using 86948-1-RR (same clone as 86948-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86948-1-RR (Cathepsin S antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86948-1-PBS in a different storage buffer formulation.

  • IF Staining of THP-1 using 86948-1-RR (same clone as 86948-1-PBS)

    IF Staining of THP-1 using 86948-1-RR (same clone as 86948-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using Cathepsin S antibody (86948-1-RR, Clone: 252053B3 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 86948-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86948-1-RR

    Affinity and Kinetic Characterization of 86948-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86948-1-RR against Human Cathepsin S were performed. The affinity constant is below 1 pM.

Cathepsin S Recombinant monoclonal antibody, PBS Only

Cathepsin S Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 86948-1-PBS

产品说明书

CloneNo. 252053B3

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

CTSS, EC:3.4.22.27

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86948-1-PBS targets Cathepsin S in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag25881

Product name: Recombinant human CTSS protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 179-296 aa of BC002642

Sequence: GCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 cathepsin S
别名 CTSS, EC:3.4.22.27
计算分子量 37 kDa
观测分子量 25 kDa, 37 kDa
GenBank蛋白编号BC002642
基因名称 CTSS
Gene ID (NCBI) 1520
RRIDAB_3745227
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP25774
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Cathepsin S (CTSS) is a cysteine protease that plays an important role in extracellular matrix degradation and remodeling, antigen presentation, inflammation, and angiogenesis; it has been identified as a radiation response gene. In malignant tumors, CTSS induces tumor proliferation, invasion and metastasis through various mechanisms. CTSS proteins could be detected in two forms, pro-CTSS (35-37 kDa) and active CTSS (25 kDa) (PMID: 30006610, PMID: 34208434). And in this publication, it was also reporeted that active CTSS was expressed at higher levels than pro-CTSS in the lysate (PMID: 34208434).

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