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验证数据展示

  • WB analysis of HEK-293 using 11688-1-AP (same clone as 11688-1-PBS)

    WB analysis of HEK-293 using 11688-1-AP (same clone as 11688-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 11688-1-AP (CYP4A11 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11688-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 11688-1-AP (same clone as 11688-1-PBS)

    IHC staining of human kidney using 11688-1-AP (same clone as 11688-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 11688-1-AP (CYP4A11 antibody) at dilution of 1:1000 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11688-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 11688-1-AP (same clone as 11688-1-PBS)

    IHC staining of human kidney using 11688-1-AP (same clone as 11688-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 11688-1-AP (CYP4A11 antibody) at dilution of 1:1000 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11688-1-PBS in a different storage buffer formulation.

CYP4A11 Polyclonal antibody, PBS Only

CYP4A11 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 11688-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

20-HETE synthase, 20-hydroxyeicosatetraenoic acid synthase, CP4Y, CYP4A14, CYP4A2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

11688-1-PBS targets CYP4A11 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag2300

Product name: Recombinant human CYP4A11 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-215 aa of BC022851

Sequence: MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFRHWQRAQHSRHLP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 cytochrome P450, family 4, subfamily A, polypeptide 11
别名 20-HETE synthase, 20-hydroxyeicosatetraenoic acid synthase, CP4Y, CYP4A14, CYP4A2
计算分子量 519 aa, 59 kDa
观测分子量 59 kDa
GenBank蛋白编号BC022851
基因名称 CYP4A11
Gene ID (NCBI) 1579
RRIDAB_10804774
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ02928
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CYP4A is a member of the CYP4 enzyme family and is involved in the metabolism of medium- and long-chain fatty acids, such as arachidonic acid, palmitate, laurate and compounds with highly regionally selective hydroxylated terminal ω-carbon (PMID: 2554928). CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS-induced lipid peroxidation and inflammation (PMID: 32124935). CYP4A11 primarily metabolizes endobiotics and catalyzes the ω-hydroxylation of fatty acids in human liver and kidney tissues (PMID: 34594219). The human CYP4A11 is homologous to mouse CYP4A14 (PMID: 38356602).

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