• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

CYP17-IN-1

CAS号

2093317-51-0

分子式

C18H17FN2S

主要靶点

P450

仅限科研使用

Cat No : CM11458

Print datasheet

Synonyms

Rat CYP17|Human CYP17|CYP17|CYP17 IN 1|CYP17IN1|CYP-17-IN-1|CYP17-IN-1

验证数据展示

  • CAS No.: 2093317-51-0

    CYP17-IN-1
    CAS#: 2093317-51-0

产品信息

CAS号 2093317-51-0
分子式 C18H17FN2S
主要靶点 P450
主要通路 代谢
分子量 312.4
纯度 99.17%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Rat CYP17|Human CYP17|CYP17|CYP17 IN 1|CYP17IN1|CYP-17-IN-1|CYP17-IN-1

靶点活性

CYP17 (human):20.1 nM |CYP17 (rat):15.8 nM

体内活性

CYP17-IN-1 dose-dependently reduced plasma testosterone levels in Sprague-Dawley rats[1].

体外活性

The IC50 value of CYP17-IN-1 for CYP3A4 is 8.5 μM[1].

溶解度

DMSO:3.12 mg/mL (10 mM)

参考文献

1.Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2