• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • FC experiment of human PBMCs using 98410-3-RR (same clone as 98410-3-PBS)

    FC experiment of human PBMCs using 98410-3-RR (same clone as 98410-3-PBS)

    1x10^6 human PBMCs were intracellularly stained with 0.25 ug Anti-Human CXCL4/PF4 Rabbit RecAb (98410-3-RR, Clone: 243087B12) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD14. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98410-3-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98410-3-RR (same clone as 98410-3-PBS)

    FC experiment of human PBMCs using 98410-3-RR (same clone as 98410-3-PBS)

    1x10^6 human PBMCs were intracellularly stained with 0.25 ug Anti-Human CXCL4/PF4 Rabbit RecAb (98410-3-RR, Clone: 243087B12) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). Monocytes were gated. This data was developed using the same antibody clone with 98410-3-PBS in a different storage buffer formulation.

Anti-Human CXCL4/PF4 Rabbit Recombinant Antibody, PBS Only

CXCL4/PF4 Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98410-3-PBS

产品说明书

CloneNo. 243087B12

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC (Intra)

别名

CXCL4, PF4, SCYB4, C X C motif chemokine 4, C-X-C motif chemokine 4

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

点击咨询售前客服

点击咨询售后客服

产品信息

98410-3-PBS targets CXCL4/PF4 in FC (Intra) applications and shows reactivity with human samples.

经测试应用 FC (Intra) Application Description
经测试反应性 human
免疫原 CXCL4/PF4 fusion protein Eg2129 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 platelet factor 4
别名 CXCL4, PF4, SCYB4, C X C motif chemokine 4, C-X-C motif chemokine 4
计算分子量11 kDa
GenBank蛋白编号NM_002619.4
基因名称 PF4
Gene ID (NCBI) 5196
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP02776
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CXCL4, also known as platelet factor 4 (PF-4), is the oldest member of the chemokine family. CXCL4 is a chemokine produced by activated platelets and immune cells involved in pathological conditions such as cancer, infections and inflammatory diseases like systemic sclerosis (SSc), rheumatoid arthritis (RA) and psoriatic arthritis (PsA), among others. CXCL4 is present in the α-granules of platelets in amounts that constitute up to 2% platelet protein mass. CXCL4 plays a determinant role in distinct physiological processes such as in hematopoiesis, angiogenesis, coagulation and modulation of immune responses. For instance, CXCL4 can prevent monocyte apoptosis and promote cell survival, induces the production of TNF and reactive oxygen species (ROS) and promotes monocyte differentiation into a unique macrophage-like phenotype.