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CU-CPT9b

CU-CPT9b (TLR8-specific antagonist 1) 是 toll 样受体 8 (TLR8) 的拮抗剂，Kd 为 21 nM。它抑制由 TLR8 激动剂 R-848 在过表达 TLR8 的 HEK-Blue 细胞中诱导的 NF-ĸB 活化，IC5​​0 值为 0.7 nM。

CAS号

2162962-69-6

分子式

C16H13NO2

主要靶点

TLR

仅限科研使用

Cat No : CM06663

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Synonyms

CU-CPT-9b|TLR8-specific antagonist 1

验证数据展示

  • CAS No.: 2162962-69-6

    CU-CPT9b
    CAS#: 2162962-69-6

产品信息

CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.

CAS号 2162962-69-6
分子式 C16H13NO2
主要靶点 TLR
主要通路 免疫与炎症
分子量 251.28
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 CU-CPT-9b|TLR8-specific antagonist 1

靶点活性

TLR8:0.7 nM (IC50)|TLR8:21 nM (Kd)

溶解度

DMSO:100 mg/mL (397.96 mM)

参考文献

1.Zhang S , Hu Z , Tanji H , et al. Small-molecule inhibition of TLR8 through stabilization of its resting state[J]. Nature Chemical Biology, 2017, 14(1):58-64.

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