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验证数据展示

  • WB analysis using 32926-1-AP (same clone as 32926-1-PBS)

    WB analysis using 32926-1-AP (same clone as 32926-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32926-1-AP (CTNNAL1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32926-1-PBS in a different storage buffer formulation.

  • WB analysis of HepG2 using 32926-1-AP (same clone as 32926-1-PBS)

    WB analysis of HepG2 using 32926-1-AP (same clone as 32926-1-PBS)

    WB result of CTNNAL1 antibody (32926-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-CTNNAL1 transfected HepG2 cells. This data was developed using the same antibody clone with 32926-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

CTNNAL1 Polyclonal antibody, PBS Only

CTNNAL1 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 32926-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

ACRP, Alpha catenin related protein, alpha CATU, Alpha catulin, Alpha-catenin-related protein

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

32926-1-PBS targets CTNNAL1 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag38629

Product name: Recombinant human CTNNAL1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 290-535 aa of NM_003798

Sequence: ISIFTGIKEFKMNIEALRENLYFQSKENLSVTLEVILERMEDFTDSAYTSHEHRERILELSTQARMELQQLISVWIQAQSKKTKSIAEELELSILKISHSLNELKKELHSTATQLAADLLKYHADHVVLKALKLTGVEGNLEALAEYACKLSEQKEQLVETCRLLRHISGTEPLEITCIHAEETFQVTGQQIISAAETLTLHPSSKIAKENLDVFCEAWESQISDMSTLLREINDVFEGRRGEKYG

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 catenin (cadherin-associated protein), alpha-like 1
别名 ACRP, Alpha catenin related protein, alpha CATU, Alpha catulin, Alpha-catenin-related protein
计算分子量82 kDa
观测分子量82 kDa
GenBank蛋白编号NM_003798
基因名称 CTNNAL1
Gene ID (NCBI) 8727
RRIDAB_3742792
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ9UBT7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Catenin alpha-like protein 1 (CTNNAL1, also known as alpha-catulin) is a cytoplasmic molecule that integrates the crosstalk between nuclear factor-kappa B (NF-κB) and Rho signaling pathways. It plays a crucial role in maintaining epithelial integrity and promoting wound repair in bronchial epithelial cells. CTNNAL1 has been shown to inhibit ozone-induced airway epithelial-mesenchymal transition and regulate mucus hypersecretion induced by house dust mite (HDM) (PMID: 38602002). Additionally, CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway (PMID: 36535402). In cancer, CTNNAL1 regulates cancer stem cells (CSCs) in lung cancer and glioblastoma, modulating their migration and invasion abilities (PMID: 37239133).

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