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验证数据展示

  • FC experiment of mouse splenocytes using 98147-1-RR (same clone as 98147-1-PBS)

    FC experiment of mouse splenocytes using 98147-1-RR (same clone as 98147-1-PBS)

    1x10^6 untreated or Con A treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CTLA-4/CD152 Rabbit Recombinant Antibody (98147-1-RR, Clone: 241100B8) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Mouse CD4. Cells were not fixed. This data was developed using the same antibody clone with 98147-1-PBS in a different storage buffer formulation.

  • FC experiment of mouse splenocytes using 98147-1-RR (same clone as 98147-1-PBS)

    FC experiment of mouse splenocytes using 98147-1-RR (same clone as 98147-1-PBS)

    1x10^6 Con A treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CTLA-4/CD152 Rabbit Recombinant Antibody (98147-1-RR, Clone: 241100B8)(red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CTLA-4/CD152 Rabbit Recombinant Antibody (98147-1-RR, Clone: 241100B8) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98147-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98147-1-RR

    Affinity and Kinetic Characterization of 98147-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98147-1-RR against Mouse CTLA-4/CD152 were performed. The affinity constant is 0.580 nM.

Anti-Mouse CTLA-4/CD152 Rabbit Recombinant Antibody, PBS Only

CTLA-4/CD152 Uni-rAb® Recombinant Antibody for FC
Cat No. 98147-1-PBS

产品说明书

CloneNo. 241100B8

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

Ctla4, 241100B8, Cd152, CTLA-4, Ly 56

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98147-1-PBS targets CTLA-4/CD152 in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原

CatNo: Eg0632

Product name: Recombinant Mouse CTLA-4 protein (His Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS

Tag: C-6*HIS

Domain: 36-162 aa of NM_009843.4

Sequence: EAIQVTQPSVVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPFCSGTFNESRVNLTIQGLRAVDTGLYLCKVELMYPPPYFVGMGNGTQIYVIDPEPCPDSDF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 cytotoxic T-lymphocyte-associated protein 4
别名 Ctla4, 241100B8, Cd152, CTLA-4, Ly 56
计算分子量25 kDa
GenBank蛋白编号NM_009843.4
基因名称 CTLA-4
Gene ID (NCBI) 12477
RRIDAB_3672292
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP09793
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CTLA-4, also known as CD152, belonging to the immunoglobulin superfamily, is primarily found on activated T cells and regulatory T cells (Tregs). CTLA-4 is closely related to the T-cell costimulatory CD28, and both molecules bind to B7-1 and B7-2 on antigen-presenting cells. CTLA-4 acts as a negative regulatory molecule of T-cell responses. Besides the full-length transmembrane form, CTLA-4 also exists in a truncated soluble form (sCTLA-4).

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